Research
Organic Chemistry
- Synthesis and characterization of active compounds using various spectroscopic methods viz. IR, NMR and Mass spectroscopic methods.
- Developing a new methodology for existing organic compounds.
Medicinal Chemistry
- Develop lead compounds for various Bioactive compounds
- Unveil the various biological activities for the Vicinal diaryl motifs
- Finding the drug in drug (Repurposing or Recycling)
- SAR and QSAR studies
Current Research
- Sialidases are enzymes which can catalyze the hydrolysis of glycosidic linkage of terminal sialic acid (N-acetylneuraminic acid) residues in oligosaccharides and other glycoconjugates. Human sialidases are four types and classified on the basis of their localization.
- NEU1 – Intralysosomal sialidase, NEU2 – Cytosolic sialidase, NEU3 – Plasma membrane-associated sialidase and NEU4 – mitochondrial membrane-associated sialidase.
- These isoforms differ in their substrate specificities, enzymatic properties, and physiological functions. Human sialidases plays a wide variety of biological processes namely cell metabolism, cell differentiation, cell growth, and apoptosis including immune functions.
- These isoforms differ in their substrate specificities, enzymatic properties, and physiological functions. Human sialidases plays a wide variety of biological processes namely cell metabolism, cell differentiation, cell growth, and apoptosis including immune functions.Sialic acids have also been found to be involved in the proliferation of cancer cells, where they are usually over-expressed on the surface glycoproteins of some cancer cell lines. Gangliosides, present on the plasma membrane of cancer cells, play an important role in the regulation of these cells. Specific human sialidase (NEU3) on gangliosides induces inhibition of apoptosis and promotes cancer cell mobility (metastasis) in some colon and rectal cancer cells.
- We are currently interested in developing selective non carbohydrate inhibitors of human sialidase (NEU3).
Past Research
Academic research
Anti-HIV agent
Anti-Severe acute respiratory syndrome agents
Vicinal / Diaryl Diazepines
Vicinal / Diaryl Diazepines
Pancuronium
Flexible semi-rigid azasteriod
Candocuronium
Methodology for N-aryl lactams
Industry Research
Dabigatran etexilate mesylate
1.Used as oral anticoagulant
2.Synthesized by new Non-infringement synthetic route
2.Synthesized by new Non-infringement synthetic route
Diflunisal
1.Used as anti-inflammatory agent
2.Successfully Cost effective process research was developed and taken to technology transfer. Impurity profile also studied.Synthesized by new Non-infringement synthetic route
Primaquine Phosphate
1.Used in Malaria and Pneumocystis pneumonia
2.Designed and executed the synthetic scheme which is highly feasible in industrial scale. The present route addressed the difficulties of the existing patent route with high yield.
2.Designed and executed the synthetic scheme which is highly feasible in industrial scale. The present route addressed the difficulties of the existing patent route with high yield.