u Dr.Ramajayam,Assistant professor| Medicinal chemistry | organic chemistry|Osaka University Japan


  • 2014
    • Faculty Development Teacher Training Course

  • 2007
    • Ph.D. in Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.

      Dissertation Title: Design, Synthesis and Biological Studies of some Novel Diazepines and Pyrimidines.

  • 2004
    • Master of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.

  • 2002
    • B. Pharmacy, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, India.

Honor and Awards

  • 2012
    Specially Appointed Assistant Professor
    from Osaka University, Osaka, Japan
  • 2011
    Received Postdoctoral Fellowship
    from National Science Council, Taiwan
  • 2009
    Received Regular Postdoctoral Fellowship
    from Academia Sinica, Taipei, Taiwan
  • 2008
    Fast Track Proposals for Young Scientists
    from DST, New Delhi, India
  • 2007
    Research Associate Fellowship
    from DST, New Delhi, India
  • 2006
    Senior Research Fellowship (SRF)
    from ICMR, New Delhi, India
  • 2004
    Junior Research Fellowship (JRF)
    from UGC, New Delhi, India
  • 2002
    Junior Research Fellowship (JRF)
    from UGC, New Delhi, India
  • 2002
    Qualified GATE-2002
    with 97.41 percentile
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Current Research

Sialidases are enzymes which can catalyze the hydrolysis of glycosidic linkage of terminal sialic acid (N-acetylneuraminic acid) residues in oligosaccharides and other glycoconjugates. Human sialidases are four types and classified on the basis of their localization.

NEU1 - Intralysosomal sialidase, NEU2 - Cytosolic sialidase, NEU3 - Plasma membrane-associated sialidase and NEU4 - mitochondrial membrane-associated sialidase.

These isoforms differ in their substrate specificities, enzymatic properties, and physiological functions. Human sialidases plays a wide variety of biological processes namely cell metabolism, cell differentiation, cell growth, and apoptosis including immune functions.

Sialic acids have also been found to be involved in the proliferation of cancer cells, where they are usually over-expressed on the surface glycoproteins of some cancer cell lines. Gangliosides, present on the plasma membrane of cancer cells, play an important role in the regulation of these cells. Specific human sialidase (NEU3) on gangliosides induces inhibition of apoptosis and promotes cancer cell mobility (metastasis) in some colon and rectal cancer cells.

We are currently interested in developing selective non carbohydrate inhibitors of human sialidase (NEU3).

Past Research

Academic research

  • Anti-HIV agent

Anti-HIV agent

  • Anti-Severe acute respiratory syndrome agents

International college Organic chemistry ProfessorNeuramininidase inhibitors

 Anti-HIV agents Anti-SARS agents,

  • Vicinal / Diaryl Diazepines

Vicinal / Diaryl Diazepines

  • Synthesis of Semi-rigid Azasteroid as a Neuromuscular Blocking Agent

Neuramininidase inhibitors Neuramininidase inhibitors Neuramininidase inhibitors

Pancuronium Candocuronium Flexible semi-rigid azasteriod

  • Methodology for N-aryl lactams

organic chemistry

Industry Research

  • Dabigatran etexilate mesylate

Used as oral anticoagulant
Synthesized by new Non-infringement synthetic route Medicinal chemistry

  • Diflunisal

Used as anti-inflammatory agent Assistant professor
Successfully Cost effective process research was developed and taken to technology transfer. Impurity profile also studied.

  • Primaquine Phosphate

Used in Malaria and Pneumocystis pneumonia Anti-SARS agents
Designed and executed the synthetic scheme which is highly feasible in industrial scale. The present route addressed the difficulties of the existing patent route with high yield.