# Dr. R. Ramajayam

> Academic Leader in Pharmaceutical Sciences | Principal | Research Mentor

With over 20 years in pharmaceutical education, leadership, and medicinal chemistry research, I advance academic excellence, global collaboration, and student mentorship through innovative curriculum design and high-impact publications.

Website: https://ramajayam.co.in
Email: rramajayam@hotmail.com
Phone: +91 87789 97750, +91 86088 56198
Location: Chennai, India
Google Scholar: https://scholar.google.com/citations?user=hgr66lQAAAAJ&hl=en

## Education
- 2014: Faculty Development Teacher Training Course
- 2007: Ph.D. in Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India. Dissertation Title: Design, Synthesis and Biological Studies of some Novel Diazepines and Pyrimidines.
- 2004: Master of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.
- 2002: B. Pharmacy, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, India.

## Academic and research positions
- Assistant Professor, Osaka University, Osaka, Japan
  - Taught undergraduate and graduate courses in the field of organic chemistry to international students.
  - Involved in the academic curriculum committee and implementation. Student selection committee member in the selection process and involved in the university promotional fair.
  - Developed organic chemistry video tutorials for chemical engineers in collaboration Sumitomo Corporation, Japan
- Postdoctoral Fellow, National Central University, Taiwan
  - Developed synthetic strategies for complex indole-based natural products with potential biological activity.
  - Acetogenins – Investigated the total synthesis of bioactive acetogenins with emphasis on developing efficient synthetic routes.
  - Advanced Organic Synthesis – Expertise in multi-step synthesis, reaction mechanism studies, and stereochemical control.
  - Natural Product Chemistry – Focused on designing efficient routes to biologically significant natural molecules.
- Postdoctoral Fellow, Academia Sinica, Taiwan
  - Contributed to the development of potential SARS-CoV and H1N1 influenza inhibitors.
  - Synthetic Analog Design – Designed and synthesized diverse pyrazolone and pyrimidinone analogs as lead candidates.
  - Medicinal Chemistry Focus – Developed efficient synthetic strategies to improve potency and selectivity of bioactive compounds.
  - Collaborative Research – Worked in a multidisciplinary setting bridging organic synthesis with biological evaluation.
- DST Fast Track Young Scientist, IIT Madras, Chennai, India
  - Awarded ₹19.86 lakhs research grant from DST as Principal Investigator.
  - Led independent research projects under the DST Fast Track scheme, advancing novel chemical synthesis and materials research.
- Team Leader, Apicore Pharmaceuticals, India
  - Lead organic chemists, developing and scaling API processes for quality and quantity.
  - Executed processes with engineers, and created/reviewed documentation.
  - Focused on cost reduction and raw material cost preparation.
- Professor, SRM University, Chennai, India
  - Taught pharmaceutical sciences, guiding research projects and academic pursuits.
  - Developed modern labs for master’s students and conducted international symposiums.
- Assistant Professor, DIT University, Dehradun, India
  - Taught pharmaceutical sciences, mentoring students in research projects.
  - Contributed to NAAC and NBA accreditation, academic reputation.

## Awards and fellowships
- 2012: Specially Appointed Assistant Professor, Osaka University, Osaka, Japan
- 2011: Received Postdoctoral Fellowship from National Science Council, Taiwan
- 2009: Received Regular Postdoctoral Fellowship from Academia Sinica, Taiwan
- 2008: Received Fast Track Proposals for Young Scientists from DST, India
- 2006: Received Senior Research Fellowship (SRF) from ICMR, New Delhi, India
- 2004: Received Junior Research Fellowship (JRF) from UGC, New Delhi, India
- 2002: Received Junior Research Fellowship (JRF) from UGC, New Delhi, India
- 2002: Qualified GATE-2002 with 97.41 percentile

## Research and grants
- DST-India Grant (2008): ₹19.86 Lakhs (USD ~51,000)
- Focus: Synthesis of Biologically Active Molecules
- Reviewer: European Journal of Medicinal Chemistry, RSC Advances
- International Experience: Japan, Taiwan, India
- Interest: Antiviral & Antiplatelet Ligands, SARS-CoV-2 Inhibitors

## Peer-reviewed publications (* = corresponding author)
- 22. R. Ramajayam *, A comprehensive review on traditional and modern synthetic approaches to pyrazole and its analogs, Journal of Heterocyclic Chemistry, 2025, 62, 1424. (Impact factor 2.4)
- 21. Shweta Mishra, Ashlesha Chauhan, R. Ramajayam, Identification, isolation and structural characterization of forced degradation products of sotorasib using advanced analytical techniques, Results in Chemistry, 2024, 11, 101799. (Impact factor 4.2)
- 20. Sandeep Yu-Cheng Chu, Rajeev Kumar Sharma, Po-Huang Liang, R. Ramajayam* Synthesis, in vitro and in silico studies of pyrazole analogs as SARS-CoV-2 inhibitors, Results in Chemistry, 2024, 9, 101649. (Impact factor 4.2)
- 19. Shweta Mishra, Ashlesha Chauhan, R. Ramajayam, Isolation, identification and structural characterization of forced degradation products of mobocertinib using LC-MS/MS and NMR, Results in Chemistry, 2024, 7, 101465. (Impact factor 4.2)
- 18. Sandeep Singh, Rajeev Kumar Sharma, R. Ramajayam*, Bis-pyrazole as receptor interacting protein 1 kinase inhibitor: Synthesis, preliminary biological evaluation against pancreatic cancer cell line and its docking studies, Results in Chemistry, 2024, 7, 101447. (Impact factor 4.2)
- 17. Sandeep Singh, Rajeev Kumar Sharma, Aishwarya Singh, Manoj Garg, R. Ramajayam* Design, synthesis and biological evaluation of vicinal-diaryl pyrazole ethyl carboxylate analogs as antiproliferative agent against pancreatic cancer, Asian Journal of Chemistry, 2024, 36, 677. (Impact factor 0.14)
- 16. Sandeep Singh, P Geetha, R. Ramajayam*, Isolation, synthesis and medicinal chemistry of biphenyl analogs: A review, Results in Chemistry, 2023, 6, 101135. (Impact factor 4.2)
- 15. Deepak Kumar, Raj Kumar, R. Ramajayam, KW Lee, DS Shin, Synthesis, antioxidant and molecular docking studies of (-)-catechin derivatives, Journal of Korean Chemical Society, 2021, 65, 106. (Impact factor 0.349)
- 14. SS Kanu, A Ojha, R. Ramajayam, S Bhargava, An updated review on trans labial mucosa: A significant area to design and deliver a drug, Journal of Pharmaceutical Sciences and Research, 2020, 12, 1425. (Scopus index)
- 13. R. Ramajayam*, A new easy method for assigning absolute configuration without the use of models, Chemistry: Bulgarian Journal of Science Education, 2019, 28, 485. (DOAJ index)
- 12. R. Ramajayam*, Medicinal chemistry of vicinal diaryl scaffold: A mini review, European Journal of Medicinal Chemistry, 2019, 162, 1. (Impact factor 6.0)
- 11. Rajani Giridhar, Riyaj S. Tamboli, R. Ramajayam, Dhaval G. Prajapati, M. R. Yadav, Assessment of antiplatelet activity of 2-aminopyrimidines, European Journal of Medicinal Chemistry, 2012, 50, 428. (Impact factor 6.0)
- 10. R. Ramajayam, Kian-Pin Tan, Po-Huang Liang, Recent development of 3CL and 3C protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery, Biochemical Society Transactions (Invited Review) 2011, 39, 1371. (Impact factor 3.9)
- 9. R. Ramajayam, Kian-Pin Tan, Hun-Ge Liu, Po-Huang Liang, Synthesis and evaluation of pyrazolone compounds as SARS coronavirus 3C-like protease inhibitors, Bioorganic Medicinal Chemistry, 2010, 18, 7849. (Impact factor 3.3)
- 8. R. Ramajayam, Kian-Pin Tan, Hun-Ge Liu, Po-Huang Liang, Synthesis, docking studies and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease, Bioorganic Medicinal Chemistry Letters, 2010, 20, 3569. (Impact factor 2.5)
- 7. R. Ramajayam, Nilesh B. Mehara, Nouri Neamati, Mange Ram Yadav, Rajani Giridhar, Synthesis and anti-HIV-I integrase activity of cyano pyrimidinones, Archiv der Pharmazie, 2009, 342, 710. (Impact factor 4.3)
- 6. Dhaval G Prajapati, R. Ramajayam, Mange Ram Yadav, Rajani Giridhar, The search for potent, small Molecule NNRTIs: A review, Bioorganic Medicinal Chemistry, 2009, 17, 5744. (Impact factor 3.3)
- 5. R. Ramajayam, Rajani Giridhar, M. R. Yadav, R. Balaraman, Hakim Djaballah, David Shum, Constantin Radu, Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines, European Journal of Medicinal Chemistry, 2008, 43, 2004. (Impact factor 6.0)
- 4. R. Ramajayam, Rajani Giridhar, M. R. Yadav, Hakim Djaballah, David Shum, Constantin Radu, Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines, Journal of Enzyme Inhibition and Medicinal Chemistry, 2007, 22, 716. (Impact factor 5.6)
- 3. R. Ramajayam, R. Giridhar, M. R. Yadav, Current Scenario of 1,4-diazepines as potent biomolecules: A mini review, Mini Reviews in Medicinal Chemistry, 2007, 7, 793. (Impact factor 3.3)
- 2. R. Ramajayam, R. Giridhar, M. R. Yadav, Synthesis of novel substituted diaryl-1,4-diazepines, Khimiya Geterotsiklicheskikh Soedinenii (Chemistry of Heterocyclic Compounds), 2006, 1042. (Impact factor 1.4)
- 1. R. Ramajayam, R. Giridhar, M. R. Yadav, Erick De Clercq, Christophe Pannecouque, Dhaval G Prajapati, ‘Identification of novel nonnucleoside reverse transcriptase inhibitors using fragment based lead generation, Medicinal Chemistry Research, 2005, 14, 475. (Impact factor 2.6)

## Conference presentations
- Sandeep Singh, Rajeev Sharma, Manoj Garg, R. Ramajayam "Bis-Pyrazole as Antiproliferative agent": Presented in 26th Annual National Convention-APTICON 2023 held at Pranveer Singh Institute of Technology, 2nd-3rd September 2023. Abstract No: PSIT/PP02/0049
- R. Ramajayam, Kian-Pin Tan, Po-Huang Liang, ‘Recent development of 3CL and 3C protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery’: Presented in Joint SinoUK Protein Society Symposium - a meeting to celebrate the centenary of the Biochemical Society, May 2011.
- R. Ramajayam, R. Giridhar, M. R. Yadav, Design, synthesis and evaluation of 2,3-diaryl-1,4-diazepines as potential antiproliferative agents. Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United States, Aug. 28-Sept. 1, 2005, MEDI-344.
- R. Ramajayam, Rajani Giridhar and Mange Ram Yadav, ‘2,3-substituted diaryl-6,7-dihydro-5H-1,4-diazepine as potential medicinal agents’ 57th Indian Pharmaceutical Congress, Hyderabad, Dec. 02 to 04 2005, Abstract no. BP-54
- Shitesh R. Patel, M. M. Ganesh, R. Ramajayam, Rajani Giridhar and Mange Ram Yadav, ‘16&dimethylamine-3-pyrrolidino-5-androstane dimethiodide as a potential neuromuscular blocking agents’ 55th Indian Pharmaceutical Congress, Chennai, Dec. 19 to 21 2003, Abstract no. BP-41

## Invited lectures
- Delivered an invited lecture on "Organic Chemistry: The Backbone Driving the Pharmacy Curriculum" at the School of Pharmacy, Sri Venkateswaraa University, Red Hills, Chennai, on 25th July 2025.
- Delivered an invited lecture on "From Reactions to Research: Rediscovering the Role of Organic Chemistry in Pharmacy Education" at KMMC College Of Pharmacy, KMMC University, Kanniyakumari, on 4th July 2025.
- Delivered a lecture and workshop on "Nuclear magnetic resonance and its application in structural elucidation" at Laureate Institute of Pharmacy, Kangra District, Himachal Pradesh, on April 01, 2024

## Pages
- [Home](https://ramajayam.co.in/)
- [About](https://ramajayam.co.in/about)
- [Experience](https://ramajayam.co.in/experience)
- [Publications](https://ramajayam.co.in/publications)
- [Presentations](https://ramajayam.co.in/presentations)
- [Awards](https://ramajayam.co.in/awards)
- [Research Interests](https://ramajayam.co.in/research-interests)
- [Grants](https://ramajayam.co.in/grants)
- [Teaching](https://ramajayam.co.in/teaching)
- [Invited Lectures](https://ramajayam.co.in/invited-lectures)
- [Gallery](https://ramajayam.co.in/gallery)
- [Portfolio](https://ramajayam.co.in/portfolio)
- [Blog](https://ramajayam.co.in/blog)
- [Contact](https://ramajayam.co.in/contact)

## Articles
- [Academic Consultancy](https://ramajayam.co.in/academic-consultancy) — Hello everyone, I am pleased to offer consultation services to individuals and organizations aiming to achieve excellence and sustainable improvement, especially in academic and research initiatives.
- [Dean of Pharmacy with NAAC experience](https://ramajayam.co.in/dean-of-pharmacy-with-naac-experience) — Dr. R. Ramajayam is a highly accomplished Dean of Pharmacy with NAAC experience, bringing over two decades of leadership in pharmaceutical sciences, institutional accreditation, and academic administration.