Dean, School of Pharmacy
Email : rramajayam@hotmail.com
Mobile : +91-8608856198
Whatsapp : +91-8778997750

Academic

  • 2014

    • Faculty Development Teacher Training Course

  • 2007

    • Ph.D. in Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.

      Dissertation Title: Design, Synthesis and Biological Studies of some Novel Diazepines and Pyrimidines.

  • 2004

    • Master of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.

  • 2002

    • B. Pharmacy, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, India.

Honor and Awards

  • 2012
    Specially Appointed Assistant Professor
    from Osaka University, Osaka, Japan
  • 2011
    Received Postdoctoral Fellowship
    from National Science Council, Taiwan
  • 2009
    Received Regular Postdoctoral Fellowship
    from Academia Sinica, Taipei, Taiwan
  • 2008
    Fast Track Proposals for Young Scientists
    from DST, New Delhi, India
  • 2007
    Research Associate Fellowship
    from DST, New Delhi, India
  • 2006
    Senior Research Fellowship (SRF)
    from ICMR, New Delhi, India
  • 2004
    Junior Research Fellowship (JRF)
    from UGC, New Delhi, India
  • 2002
    Junior Research Fellowship (JRF)
    from UGC, New Delhi, India
  • 2002
    Qualified GATE-2002
    with 97.41 percentile
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Experience

  • 2016 Professor

    SRM University, Chennai, India (January 2016 to March 2017)

  • 2012 Assistant Professor

    Osaka University, Japan (November 2012 to October 2015)

  • 2012Team Leader

    Apicore Pharmaceuticals Ltd, Vadodara, Gujarat, India (January 2012 to October 2012)

  • 2011 Senior Research Associate

    Apicore Pharmaceuticals Ltd, Vadodara, Gujarat, India (December 2011 to January 2012)

  • 2011Postdoctoral Fellow

    Department of Chemistry, National Central University, Taiwan (August 2011 to November 2011)

  • 2009 Postdoctoral Fellow

    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan (August 2009 to July 2011)

  • 2008Postdoctoral Fellow

    Department of Science and Technology (DST), Government of India, New Delhi, for the project entitled Schmidt Reaction Based Strategy for the Synthesis of Biologically Active Molecules at IIT Madras, Chennai (July, 2008 to August 2009)

  • 2007Research Associate

    Department of Science and Technology (DST), for the project entitled “Unit of Nanoscience and Technology at IIT Madras, Chennai (November 2007 to July 2008)

Research Grants

  • Title

    • Schmidt Based Strategy for the Synthesis of Biologically Active Moleculess

  • Funding Agency

    • Department of Science and Technology, Govt. of India

  • Amount

    • Rs.19.86 (lakhs)

Publications

(* = Corresponding Author)

  • 20. Sandeep Singh, Yu-Cheng Chu, Rajeev Kumar Sharma, Po-Huang Liang, R. Ramajayam*, Synthesis, in vitro and in silico studies of pyrazole analogs as SARS-CoV-2 inhibitors, Results in Chemistry, 2024, 9, 101649.

  • 19. Shweta Mishra, Ashlesha Chauhan, R. Ramajayam, Isolation, identification and structural characterization of forced degradation products of mobocertinib using LC-MS/MS and NMR, Results in Chemistry, 2024, 7, 101465.

  • 18. Sandeep Singh, Rajeev Kumar Sharma,R. Ramajayam*, Bis-pyrazole as receptor interacting protein 1 kinase inhibitor: Synthesis, preliminary biological evaluation against pancreatic cancer cell line and its docking studies, Results in Chemistry, 2024, 7, 101447.

  • 17. Sandeep Singh, Rajeev Kumar Sharma, Aishwarya Singh, Manoj Garg, R. Ramajayam*, Design, Synthesis and Biological Evaluation of vicinal-Diaryl Pyrazole Ethyl Carboxylate Analogs as Antiproliferative Agent against Pancreatic Cancer, Asian Journal of Chemistry, 2024, 36, 677.

  • 16. Sandeep Singh, P Geetha, R. Ramajayam*, Isolation, synthesis and medicinal chemistry of biphenyl analogsA review, Results in Chemistry, 2023, 6, 101135.

  • 15. Deepak Kumar, Raj Kumar, R. Ramajayam, KW Lee, DS Shin, Synthesis, Antioxidant and Molecular Docking Studies of ()-Catechin Derivatives, Journal of Korean Chemical Society, 2021, 65, 106.

  • 14. SS Kanu, A Ojha, R. Ramajayam, S Bhargava, An Updated Review on Trans Labial Mucosa: A Significant Area to Design and Deliver a Drug, Journal of Pharmaceutical Sciences and Research, 2020, 12, 1425.

  • 13. R. Ramajayam*, A New Easy Method for Assigning Absolute Configuration without the Use of Models, Chemistry: Bulgarian Journal of Science Education, 2019, 28, 485.

  • 12. R. Ramajayam*, Medicinal chemistry of vicinal diaryl scaffold: A mini review European Journal of Medicinal Chemistry, 2019, 162, 1.

  • 11. Rajani Giridhar, Riyaj S. Tamboli, R Ramajayam, Dhaval G. Prajapati, M. R. Yadav Assessment of antiplatelet activity of 2-aminopyrimidines’ European Journal of Medicinal Chemistry, 2012, 50, 428.

  • 10. R. Ramajayam, Kian-Pin Tan, Po-Huang Liang ‘Recent development of 3CL and 3C protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery’ Biochemical Society Transactions (Invited Review) 2011, 39, 1371.

  • 9. R. Ramajayam, Kian-Pin Tan, Hun-Ge Liu, Po-Huang Liang, ‘Synthesis and Evaluation of Pyrazolone Compounds as SARS Coronavirus 3C-like Protease Inhibitors’ Bioorganic Medicinal Chemistry, 2010, 18, 7849.

  • 8. R. Ramajayam, Kian-Pin Tan, Hun-Ge Liu, Po-Huang Liang, Synthesis, docking studies and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease Bioorganic Medicinal Chemistry Letters, 2010, 20, 3569.

  • 7. R. Ramajayam, Nilesh B. Mehara, Nouri Neamati, Mange Ram Yadav, Rajani Giridhar, ‘Synthesis and Anti-HIV-1 Integrase Activitiy of Cyano Pyrimidinones- Archiv der Pharmazie, 2009, 342, 710.

  • 6. Dhaval G Prajapati, R. Ramajayam, Mange Ram Yadav, Rajani Giridhar, The Search for Potent, Small Molecule NNRTIs: A Review’- Bioorganic Medicinal Chemistry, 2009, 17, 5744.

  • 5. R. Ramajayam, Rajani Giridhar, M. R. Yadav, R. Balaraman, Hakim Djaballah, David Shum, Constantin Radu, ‘Synthesis, Antileukemic and Antiplatelet activities of 2,3-diaryl-6,7-dihydro- 5H-1,4-diazepines’-European Journal of Medicinal Chemistry, 2008, 43, 2004.

  • 4. R. Ramajayam, Rajani Giridhar, M. R. Yadav, Hakim Djaballah, David Shum, Constantin Radu, Synthesis and Antiproliferative Activity of some Diaryldiazepines and Diarylpyrimidines’- Journal of Enzyme Inhibition and Medicinal Chemistry, 2007, 22, 716.

  • 3. R. Ramajayam, R.Giridhar, M. R. Yadav, Current Scenario of 1,4-diazepines as potent biomolecules-A mini review- Mini Reviews in Medicinal Chemistry, 2007, 7, 793.

  • 2. R. Ramajayam, R.Giridhar, M. R. Yadav, Synthesis of Novel Substituted Diaryl-1,4- diazepines-Khimiya Geterotsiklicheskikh Soedinenii (Chemistry of Heterocyclic Compounds), 2006, 1042.

  • 1. R. Ramajayam, R. Giridhar, M. R. Yadav, Erick De Clercq, Christophe Pannecouque, Dhaval G Prajapati, Identification of Novel Non-Nucleoside Reverse Transcriptase Inhibitors Using Fragment-Based Lead Generation- Medicinal Chemistry Research, 2005, 14, 475.

Presentations

  • R. Ramajayam, Kian-Pin Tan, Po-Huang Liang Recent development of 3CL and 3C protease inhibitors for anti-coronavirus and anti- picornavirus drug discovery: Presented in Joint Sino-UK Protein Society Symposium a meeting to celebrate the centenary of the Biochemical Society, May 2011.

  • R. Ramajayam, R. Giridhar, M. R.Yadav, Design, synthesis and evaluation of 2,3-diaryl-1,4-diazepines as potential antiproliferative agents. Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United States, Aug. 28-Sept. 1, 2005 (2005), MEDI-344.

  • R. Ramajayam, Rajani Giridhar and Mange Ram Yadav, ‘2,3-substituted diaryl-6,7-dihydro-5H-1,4-diazepine as potential medicinal agents’ 57th Indian Pharmaceutical Congress, Hyderabad, Dec. 02 to 04 2005, Abstract no. BP-54.

  • Shitesh R. Patel, M.M.Ganesh, R.Ramajayam, Rajani Giridhar and Mange Ram Yadav, ‘16-dimethylamine-3-pyrrolidino-5-androstane dimethiodide as a potential neuromuscular blocking agents’ 55th Indian Pharmaceutical Congress, Chennai, Dec. 19 to 21 2003, Abstract no. BP-41.

Courses Taught

  • Introductory chemistry experiments

    Introductory chemistry experiments are for the freshman students who will introduce to various methods and procedures used in the present day organic chemistry laboratories. They will explore the reactivity of organic compounds including common methods of separation, purification, and instrumental analysis. It covers the general techniques of organic synthesis and the use of common spectroscopic instrumentation. Students synthesize a variety of compounds and analyze the products through physical properties and spectroscopy. The course duration is seven week in a semester.

  • Organic Chemistry 1

    Organic Chemistry 1 is the compulsory first semester course for second year CBCMP students. This course focused on current theories of structure and mechanism in organic chemistry. The course emphasizes reaction mechanisms. Organic chemistry 1 course covers structure and bonding in organic molecules, reactivity, Functional group, stereoisomers, the chemistry of hydrocarbons (alkanes, alkenes, alkynes), alkyl halides and basic spectroscopy. The aim of the course is to develop for students who seeking professional degrees in chemistry and biology. Lecture is 3 hours per week. Total 15 weeks in a semester.

  • Organic Chemistry 2

    Organic Chemistry 2 is an optional second semester course for second year students. This course covers Delocalized Pi electron systems, aromaticity and the reactions of arenes, aldehydes, ketones, carboxylic acids and their derivatives, amines and heterocycles and their spectroscopy. Lecture is 3 hours per week. Total 15 weeks in a semester.

  • Organic Chemistry 3

    Organic Chemistry 3 is the advanced level and an optional course for third year students. The aim of this course is to give students an understanding of more advanced areas of organic synthesis. Key areas covered include: Oxidation and Reduction; Rearrangement reactions; Retrosynthesis; Reactions involved in synthesis of some pharmaceutical importance drugs and Natural products. A plenary lecture from invited speakers will be arranged for third year students to gain advance knowledge in the interdisciplinary research. Lecture is 3 hours per week. Total 15 weeks in a semester.

Orgainc Chemistry, 6th edition, by Peter Vollhardt & Neil Schore.

Global Dean of Pharmacy

Research Interests

Organic Chemistry

  • Synthesis and characterization of active compounds using various spectroscopic methods viz. IR, NMR and Mass spectroscopic methods.
  • Developing a new methodology for existing organic compounds.

Medicinal Chemistry

  • Develop lead compounds for various Bioactive compounds
  • Unveil the various biological activities for the Vicinal diaryl motifs
  • Finding the drug in drug (Repurposing or Recycling)
  • SAR and QSAR studies

Current Research


Sialidases are enzymes which can catalyze the hydrolysis of glycosidic linkage of terminal sialic acid (N-acetylneuraminic acid) residues in oligosaccharides and other glycoconjugates. Human sialidases are four types and classified on the basis of their localization.

NEU1 - Intralysosomal sialidase, NEU2 - Cytosolic sialidase, NEU3 - Plasma membrane-associated sialidase and NEU4 - mitochondrial membrane-associated sialidase.

These isoforms differ in their substrate specificities, enzymatic properties, and physiological functions. Human sialidases plays a wide variety of biological processes namely cell metabolism, cell differentiation, cell growth, and apoptosis including immune functions.

Sialic acids have also been found to be involved in the proliferation of cancer cells, where they are usually over-expressed on the surface glycoproteins of some cancer cell lines. Gangliosides, present on the plasma membrane of cancer cells, play an important role in the regulation of these cells. Specific human sialidase (NEU3) on gangliosides induces inhibition of apoptosis and promotes cancer cell mobility (metastasis) in some colon and rectal cancer cells.

We are currently interested in developing selective non carbohydrate inhibitors of human sialidase (NEU3).

Past Research

Academic research

  • Anti-HIV agent

Experienced Dean for leading pharmacy colleges

  • Anti-Severe acute respiratory syndrome agents

International college Organic chemistry ProfessorUSA,Japan,India Dean of Pharmacy

Dr.Ramajayam,Dean of Pharmacy Anti-SARS agents,

  • Vicinal / Diaryl Diazepines

Vicinal / Diaryl Diazepines

  • Synthesis of Semi-rigid Azasteroid as a Neuromuscular Blocking Agent

Experienced Director in Pharmaceutical Education USA,Canada Pharmacy College Leadership Profile

Pancuronium Candocuronium Flexible semi-rigid azasteriod

  • Methodology for N-aryl lactams

Global Dean of Pharmacy

Industry Research

  • Dabigatran etexilate mesylate

Used as oral anticoagulant
Synthesized by new Non-infringement synthetic route Medicinal chemistry

  • Diflunisal

Used as anti-inflammatory agent International Academic Director
Successfully Cost effective process research was developed and taken to technology transfer. Impurity profile also studied.

  • Primaquine Phosphate

Used in Malaria and Pneumocystis pneumonia University Director Positions Global
Designed and executed the synthetic scheme which is highly feasible in industrial scale. The present route addressed the difficulties of the existing patent route with high yield.